IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design
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چکیده
منابع مشابه
IgG light chain-independent secretion of heavy chain dimers: consequence for therapeutic antibody production and design
Rodent monoclonal antibodies with specificity towards important biological targets are developed for therapeutic use by a process of humanisation. This process involves the creation of molecules, which retain the specificity of the rodent antibody but contain predominantly human coding sequence. Here, we show that some humanised heavy chains (HCs) can fold, form dimers and be secreted even in t...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2017
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bcj20170342